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International Journal of Evolutionary Biology
Volume 2012, Article ID 298147, 12 pages
http://dx.doi.org/10.1155/2012/298147
Research Article

Evolution of the FGF Gene Family

CNRS, UMR 7232, BIOM, Université Pierre et Marie Curie Paris 06, Observatoire Océanologique, 66650 Banyuls-sur-Mer, France

Received 27 April 2012; Accepted 6 June 2012

Academic Editor: Frédéric Brunet

Copyright © 2012 Silvan Oulion et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Supplementary Material

Figure 1: Phylogenetic relationships of vertebrate and cnidarian FGF genes. FGF1/2 and FGF8/17/18/24 families are yellow boxed. The aLRT support for the nodes of these families is encircled in red.

Figure 2: Phylogenetic relationships of vertebrate and protostome FGF genes. FGF1/2, FGF8/17/18/24 and FGF9/16/20 families are yellow boxed. The aLRT support for the nodes of these families is encircled in red.

Figure 3: Phylogenetic relationships of vertebrate and hemichordate FGF genes. FGF8/17/18/24 and FGF9/16/20 families are yellow boxed. The aLRT support for the nodes of these families is encircled in red.

Figure 4: Phylogenetic relationships of vertebrate and Oikopleura FGF genes. FGF11/12/13/14 and FGF9/16/20 families are yellow boxed. The aLRT support for the nodes of these families is encircled in red.

Figure 5: Phylogenetic relationships of vertebrate FGFs. Maximum likelihood tree showing the classification into eight subfamilies of the different vertebrate FGF genes (i.e. FGF1/2, FGF3, FGF4/5/6, FGF7/10/22, FGF8/17/18/24, FGF9/16/20, FGF11/12/13/14 and FGF19/21/23). Sequences of Homo sapiens, Mus musculus, Bos taurus, Gallus gallus, Xenopus tropicalis, and Danio rerio were used to perform the phylogeny. Branches of the eight subfamilies are highly supported (at least 68 %) but internal branches within the different subfamilies do not always follow the evolution of species.

  1. Supplementary Figure 1
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  5. Supplementary Figure 5