Review Article
Alternative Splicing: A Potential Source of Functional Innovation in the Eukaryotic Genome
Table 1
Summary for the relationship between AS and GFS.
| Species | Data | Alternative splicing | Orthology | Bias control | Correlation | Reference |
| Human | Ensembl | ASD’s AltSplice database | BLSATP | Exons, EST coverage, gene family size, isoform count | Negative correlation | [75] | NCBI, UCSC | GeneSplicer program | EnsMart | Remove garbage EST, EST coverage, | Negative correlation | [65] | H-InvDB 5.0 | H-InvDB 5.0 | BLAST | | Positive correlation when includes all gene families. Negative correlation within multigene families | [76] | Mouse | Ensembl | ASD's AltSplice database | BLSATP | Exons, EST coverage, gene family size, isoform count | Negative correlation | [75] | NCBI, UCSC | GeneSplicer program | EnsMart | Remove garbage EST, EST coverage, | Negative correlation | [65] | Riken’s FANTOM3 | Riken’s FANTOM3 | BLAST | | Positive correlation when includes all gene families. Negative correlation within multigene families | [76] | C. elegans | WormPep | WormPep | BLAST | | Lower AS occurrence in multigene families | [77] | Rice | TIGR 4.0 | PASA program | BLASTP | Remove genes that lack transcript evidence | Multigene families have significantly higher AS incidence than singletons | [78] | Arabidopsis | TAIR7 | TAIR7 | TAIR7 | | Multigene families have significantly higher AS incidence than singletons | [78] |
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