International Journal of Evolutionary Biology / 2012 / Article / Tab 1

Review Article

Alternative Splicing: A Potential Source of Functional Innovation in the Eukaryotic Genome

Table 1

Summary for the relationship between AS and GFS.

SpeciesDataAlternative splicingOrthologyBias controlCorrelationReference

HumanEnsemblASD’s AltSplice databaseBLSATPExons, EST coverage, gene family size, isoform countNegative correlation[75]
NCBI, UCSCGeneSplicer programEnsMartRemove garbage EST, EST coverage,Negative correlation[65]
H-InvDB 5.0H-InvDB 5.0BLASTPositive correlation when includes all gene families. Negative correlation within multigene families[76]
MouseEnsemblASD's AltSplice databaseBLSATPExons, EST coverage, gene family size, isoform countNegative correlation[75]
NCBI, UCSCGeneSplicer programEnsMartRemove garbage EST, EST coverage,Negative correlation[65]
Riken’s FANTOM3Riken’s FANTOM3BLASTPositive correlation when includes all gene families. Negative correlation within multigene families[76]
C.  elegans WormPepWormPepBLASTLower AS occurrence in multigene families[77]
RiceTIGR 4.0PASA programBLASTPRemove genes that lack transcript evidenceMultigene families have significantly higher AS incidence than singletons[78]
ArabidopsisTAIR7TAIR7TAIR7Multigene families have significantly higher AS incidence than singletons[78]

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