Alternative Splicing: A Potential Source of Functional Innovation in the Eukaryotic Genome

Table 1

Summary for the relationship between AS and GFS.

Species	Data	Alternative splicing	Orthology	Bias control	Correlation	Reference
Human	Ensembl	ASD’s AltSplice database	BLSATP	Exons, EST coverage, gene family size, isoform count	Negative correlation	[75]
	NCBI, UCSC	GeneSplicer program	EnsMart	Remove garbage EST, EST coverage,	Negative correlation	[65]
	H-InvDB 5.0	H-InvDB 5.0	BLAST		Positive correlation when includes all gene families. Negative correlation within multigene families	[76]
Mouse	Ensembl	ASD's AltSplice database	BLSATP	Exons, EST coverage, gene family size, isoform count	Negative correlation	[75]
	NCBI, UCSC	GeneSplicer program	EnsMart	Remove garbage EST, EST coverage,	Negative correlation	[65]
	Riken’s FANTOM3	Riken’s FANTOM3	BLAST		Positive correlation when includes all gene families. Negative correlation within multigene families	[76]
C.  elegans	WormPep	WormPep	BLAST		Lower AS occurrence in multigene families	[77]
Rice	TIGR 4.0	PASA program	BLASTP	Remove genes that lack transcript evidence	Multigene families have significantly higher AS incidence than singletons	[78]
Arabidopsis	TAIR7	TAIR7	TAIR7		Multigene families have significantly higher AS incidence than singletons	[78]