Evolution of Lysine Biosynthesis in the Phylum Deinococcus-Thermus

Table 1

Genes for lysine biosynthesis through the α-aminoadipate pathway in the Deinococcus-Thermus phylum.

Organism	Enzyme 1	Enzyme 2	Enzyme 3	Enzyme 4	Enzyme 5	Enzyme 6	Enzyme 7	Enzyme 8	Enzyme 9	Enzyme 10
Thermus thermophilus HB27	TTC0043	TTC1012	TTC1393	TTC1396	TTC1541*	TTC1542*	TTC1543*	TTC1546*	TTC1547*	TTC1550*
Thermus thermophilus HB8	TTHA0411	TTHA1378	TTHA1755	TTHA1757	TTHA1903*	TTHA1904*	TTHA1907*	TTHA1910*	TTHA1911*	TTHA1914*
Thermus scotoductus	TSC_c05810	TSC_c20650	TSC_c03550	TSC_c3520	TSC_c01940*	TSC_c01930*	TSC_c01920*	TSC_c01890*	TSC_c01880*	TSC_c01850*
Meiothermus ruber	Mrub_0871	Mrub_2738		Mrub_0027	Mrub_2721*	Mrub_2723*	Mrub_2724*	Mrub_2727*	Mrub_2728*
Meiothermus silvanus	Mesil_2567	Mesil_1337	Mesil_0348	Mesil_0347	Mesil_0435*	Mesil_0436*	Mesil_0438*	Mesil_0441*	Mesil_0442*
Oceanithermus profundus		Ocepr_1387	Ocepr_1797*	Ocepr_1798*	Ocepr_1796*	Ocepr_1788*	Ocepr_1784*	Ocepr_1781*	Ocepr_1780*	Ocepr_1779*
Marinithermus hydrothermalis		Marky_1533	Marky_0665*	Marky_0663*	Marky_0666*	Marky_0667*	Marky_0668*	Marky_0671*	Marky_0672*	Marky_0673*
Deinococcus radiodurans		DR_1674	DR_0794	DR_1413	DR_1420	DR_0963	DR_2194	DR_1614	DR_1610	DR_1238
Deinococcus geothermalis	Dgeo_2084	Dgeo_1458	Dgeo_1416	Dgeo_1391	Dgeo_0678	Dgeo_0685	Dgeo_1151*	Dgeo_1154*	Dgeo_1156*	Dgeo_1257
Deinococcus deserti		Deide_09240	Deide_16910	Deide_17960	Deide_10430	Deide_10350	Deide_13430*	Deide_13460*	Deide_13470*	Deide_13980
Deinococcus maricopensis	Deima_0046	Deima_1545	Deima_2454	Deima_2593	Deima_1346*	Deima_1349*	Deima_1350*	Deima_1353*	Deima_1355*	Deima_1358*
Deinococcus proteolyticus	Deipr_0213
Truepera radiovictrix		Trad_2841	Trad_1401*	Trad_1404*	Trad_1399*	Trad_1395*	Trad_1392*	Trad_1390*	Trad_1389*	Trad_1388*

Enzyme 1, α-aminoadipate aminotransferase.
Enzyme 2, Homoisocitrate dehydrogenase.
Enzyme 3, LysW-γ-L-lysine aminotransferase.
Enzyme 4, LysW-γ-L-lysine hydrolase.
Enzyme 5, LysW-γ-L-α-aminoadipate kinase.
Enzyme 6, LysW-γ-L-α-aminoadipyl-6-phosphate reductase.
Enzyme 7, α-aminoadipate-LysW ligase LysX.
Enzyme 8, LysU.
Enzyme 9, LysT.
Enzyme 10, Homocitrate synthase.
*More than 3 genes are clustered.