Table of Contents
International Journal of Evolutionary Biology
Volume 2014 (2014), Article ID 284170, 8 pages
http://dx.doi.org/10.1155/2014/284170
Research Article

Mycobacterium tuberculosis H37Rv: In Silico Drug Targets Identification by Metabolic Pathways Analysis

Department of Biotechnology, Meerut Institute of Engineering and Technology, N.H. 58, Delhi-Roorkee Highway, Baghpat Road Bypass Crossing, Meerut 250005, India

Received 10 May 2013; Revised 26 October 2013; Accepted 26 December 2013; Published 25 February 2014

Academic Editor: Graziano Pesole

Copyright © 2014 Asad Amir et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. S. H. E. Kaufmann, “Envisioning future strategies for vaccination against tuberculosis,” Nature Reviews Immunology, vol. 6, no. 9, pp. 699–704, 2006. View at Publisher · View at Google Scholar · View at Scopus
  2. B. Greenwood, “A global action plan for the prevention and control of pneumonia,” Bulletin of the World Health Organization, vol. 86, no. 5, p. 322, 2008. View at Publisher · View at Google Scholar · View at Scopus
  3. P. Nunn, B. Williams, K. Floyd, C. Dye, G. Elzinga, and M. Raviglione, “Tuberculosis control in the era of HIV,” Nature Reviews Immunology, vol. 5, no. 10, pp. 819–826, 2005. View at Publisher · View at Google Scholar · View at Scopus
  4. A. M. Feist and B. Palsson, “The growing scope of applications of genome-scale metabolic reconstructions using Escherichia coli,” Nature Biotechnology, vol. 26, no. 6, pp. 659–667, 2008. View at Publisher · View at Google Scholar · View at Scopus
  5. A. Dutta, S. K. Singh, P. Ghosh, R. Mukherjee, S. Mitter, and D. Bandyopadhyay, “In silico identification of potential therapeutic targets in the human pathogen Helicobacter pylori,” In Silico Biology, vol. 6, no. 1-2, pp. 43–47, 2006. View at Google Scholar · View at Scopus
  6. Ö. Ates, E. T. Oner, and K. Y. Arga, “Genome-scale reconstruction of metabolic network for a halophilic extremophile, Chromohalobacter salexigens DSM 3043,” BMC Systems Biology, vol. 5, article 12, 2011. View at Publisher · View at Google Scholar · View at Scopus
  7. A. Raghunathan, J. Reed, S. Shin, B. Palsson, and S. Daefler, “Constraint-based analysis of metabolic capacity of Salmonella typhimurium during host-pathogen interaction,” BMC Systems Biology, vol. 3, article 38, 2009. View at Publisher · View at Google Scholar · View at Scopus
  8. A. M. Feist, C. S. Henry, J. L. Reed et al., “A genome-scale metabolic reconstruction for Escherichia coli K-12 MG1655 that accounts for 1260 ORFs and thermodynamic information,” Molecular Systems Biology, vol. 3, article 121, 2007. View at Publisher · View at Google Scholar · View at Scopus
  9. N. C. Duarte, M. J. Herrgård, and B. Ø. Palsson, “Reconstruction and validation of Saccharomyces cerevisiae iND750, a fully compartmentalized genome-scale metabolic model,” Genome Research, vol. 14, no. 7, pp. 1298–1309, 2004. View at Publisher · View at Google Scholar · View at Scopus
  10. A. K. Chavali, J. D. Whittemore, J. A. Eddy, K. T. Williams, and J. A. Papin, “Systems analysis of metabolism in the pathogenic trypanosomatid Leishmania major,” Molecular Systems Biology, vol. 4, article 177, 2008. View at Publisher · View at Google Scholar · View at Scopus
  11. K. R. Sakharkar, M. K. Sakharkar, and V. T. K. Chow, “A novel genomics approach for the identification of drug targets in pathogens, with special reference to Pseudomonas aeruginosa,” In Silico Biology, vol. 4, no. 3, pp. 355–360, 2004. View at Google Scholar · View at Scopus
  12. M. Y. Galperin and E. V. Koonin, “Searching for drug targets in microbial genomes,” Current Opinion in Biotechnology, vol. 10, no. 6, pp. 571–578, 1999. View at Publisher · View at Google Scholar · View at Scopus
  13. M. Kanehisa, S. Goto, S. Kawashima, and A. Nakaya, “Thed KEGG databases at GenomeNet,” Nucleic Acids Research, vol. 30, no. 1, pp. 42–46, 2002. View at Google Scholar · View at Scopus
  14. R. Zhang, H.-Y. Ou, and C.-T. Zhang, “DEG: a database of essential genes,” Nucleic Acids Research, vol. 32, pp. D271–D272, 2004. View at Google Scholar · View at Scopus