Table 1: Actual conditions to which humans are not well adapted and disease to which we are at a higher risk of developing due to current environmental conditions.

Condition to which humans are not well adaptedEnvironmental
conditions to which humans adapted
Risk derived from poor adaptation to conditionsReference

Low-grade chronic inflammationGreat infectious burden with an active immune systemLow-grade systemic inflammation that leads to metabolic syndrome, diabetes, cardiovascular diseases, and hypertension[1, 21]

Abundant diet high in carbohydratesFamine and necessity to store fatIncreased risk of obesity, insulin resistance, metabolic syndrome, and type 2 diabetes [5]

SedentarismHigh physical activityInsulin resistance, obesity, metabolic syndrome, and type 2 diabetes [1]

Diet high in saltLittle salt in the dietHypertension[22]

BipedalismQuadruped movementOrthostatic intolerance and hypertension [23]

LongevityShorter lifespanIncreased exposure to the abovementioned risk factors[12]