Table of Contents
International Journal of Engineering Mathematics
Volume 2013, Article ID 132827, 8 pages
Research Article

Mathematical Modeling and Analysis of the Kinetics of Thermal Inactivation of Enzyme

1Department of Mathematics, The Madura College, Madurai, Tamilnadu 625011, India
2Department of Mathematics, Sri Ramakrishna Institute of Technology, Coimbatore, Tamilnadu 641010, India

Received 22 March 2013; Accepted 4 July 2013

Academic Editor: Yurong Liu

Copyright © 2013 S. P. Ananthi et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


A theoretical model of Illeova et al. (2003) thermal inactivation of urease is discussed. Analytical expressions pertaining to the molar concentrations of the native and denatured enzyme are obtained in terms of second-order reaction rate constant. Simple and closed form of theoretical expression pertains to the temperature are also derived. In this paper, homotopy analysis method (HAM) is used to obtain approximate solutions for a nonlinear ordinary differential equation. The obtained approximate result in comparison with the numerical ones is found to be in satisfactory agreement.