Facile Access to Aldol Products from Aromatic and Heteroaromatic Aldehydes Using Ruthenium Catalyst

Table 2

Ruthenium-catalyzed cross-aldol reaction in the presence of RuCl3⋅nH2O/3PPh3 (3a–i).

Entry^a	Aldehyde	Product	Time (h)	Yield (%)^b
1	4-(Methylthio)benzaldehyde	3a	3	82
2	3-Methylthiophen-2-carbaldehyde	3b	3.5	78
3	5-Methylthiophen-2-carbaldehyde	3c	4	80
4	Thiophen-2-carbaldehyde	3d	3.5	84
5	Furan-2-carbaldehyde	3e	3.5	77
6	4-Methoxybenzaldehyde	3f	3	80
7	4-Methylybenzaldehyde	3g	3.5	81
8	2-Methoxybenzaldehyde	3h	3.5	77
9	Benzaldehyde	3i	3	83

^aAll products were characterized by ¹H NMR, ¹³C NMR, and IR data. ^bYields after purification by chromatography.