Research Article
Facile Access to Aldol Products from Aromatic and Heteroaromatic Aldehydes Using Ruthenium Catalyst
Table 2
Ruthenium-catalyzed cross-aldol reaction in the presence of RuCl3
nH2O/3PPh3
(3a–i).
| Entr | Aldehyde | Product | Time (h) | Yield (% |
| 1 | 4-(Methylthio)benzaldehyde | 3a | 3 | 82 | 2 | 3-Methylthiophen-2-carbaldehyde | 3b | 3.5 | 78 | 3 | 5-Methylthiophen-2-carbaldehyde | 3c | 4 | 80 | 4 | Thiophen-2-carbaldehyde | 3d | 3.5 | 84 | 5 | Furan-2-carbaldehyde | 3e | 3.5 | 77 | 6 | 4-Methoxybenzaldehyde | 3f | 3 | 80 | 7 | 4-Methylybenzaldehyde | 3g | 3.5 | 81 | 8 | 2-Methoxybenzaldehyde | 3h | 3.5 | 77 | 9 | Benzaldehyde | 3i | 3 | 83 |
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ll products were characterized by 1H NMR, 13C NMR, and IR data. ields after purification by chromatography.
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