Insights into DNA Platination within Unusual Structural Settings

Table 1

¹⁵N/¹H chemical shifts of 2D [¹H, ¹⁵N] HSQC NMR cross-peaks for the reactions of dimer nucleic acids with [Pt(¹⁵NH₃)₂I₂].

Sample	Code	Complex	Peak	δ(^15N/^1H)	^15N trans to
	I	cis-[Pt(^15NH3)2I2]		−52.12/3.99	I
		cis-[Pt(^15NH3)2I(H2O)]^+	1	−47.51/4.08	I
			2	−90.09/3.70	O
d(GpG)	II	cis-[Pt(^15NH3)2{d(GpG)}-N7,N7]^2+	3	−68.13/4.43	N
			4	−68.51/4.35	N
R,S-d(GsG)	IIs	cis-[Pt(^15NH3)2{d(GsG)}-S,N7]^2+	5	−50.10/4.35	S
			6	−69.33/4.15	N
d(GpA)	III	cis-[Pt(^15NH3)2{d(GpA)}-G-N7,A-N7]^2+	7	−65.88/4.48	N
			8	−66.55/4.43	N
R,S-d(GsA)	IIIs	cis-[Pt(^15NH3)2{d(GsA)}-I,S]^+	—	−47.44/4.10*	S
				−54.46/3.95	I
d(GpT)	IV	cis-[Pt(^15NH3)2I{d(GpT)}-T-N3]^+	9	−48.22/4.26	I
			10	−76.13/4.05	N
R,S-d(GsT)	IVs	R or S cis-[Pt(^15NH3)2{d(GsT)}-T-N3,S]^2+	11	−46.55/4.34	S
			12	−67.05/4.18	N
		S or R cis-[Pt(^15NH3)2{d(GsT)}-T-N3,S]^2+	13	−46.25/4.35	S
			14	−65.97/4.17	N

*Representative value.