Coordination Chemistry of Polyaromatic Thiosemicarbazones 2: Synthesis and Biological Activity of Zinc, Cobalt, and Copper Complexes of 1-(Naphthalene-2-yl)ethanone Thiosemicarbazone

Table 3

IC₅₀ values (μM) representing the antiproliferative activity of all the complexes in a panel of three human cell lines—2 tumorigenic (HCT-116 and Caco-2) and one noncancerous (CCD-18Co).

	IC50
Complex	HCT-116			Caco-2			CCD-18Co
	24 h	48 h	72 h	24 h	48 h	72 h	24 h	48 h	72 h
1	20.6 ± 2.6	13.7 ± 2.3	10.8 ± 1.4	15.6 ± 2.1	8.5 ± 2.4	5.4 ± 0.4	16.3 ± 3.0	7.5 ± 0.7	5.0 ± 1.5
2	60.7 ± 2.5	20.4 ± 4.8	8.5 ± 0.5	56.3 ± 3.3	15.2 ± 3.2	5.6 ± 0.7	59.4 ± 1.6	16.2 ± 1.9	7.8 ± 1.0
3	3.7 ± 0.8	2.6 ± 0.5	1.5 ± 0.5	3.0 ± 0.1	1.5 ± 0.7	1.0 ± 0.1	2.8 ± 0.3	1.7 ± 0.2	1.1 ± 0.2
Etoposide	29.6 ± 1.7	23.3 ± 1.1	19.3 ± 1.5	21.8 ± 2.2	15.3 ± 0.9	14.0 ± 1.3	48.4 ±1.2	43.7 ± 1.7	40.3 ± 2.0

Each assay was carried out utilizing the MTS method following a 24-, 48- or 72-hour drug-incubation period at 37°C. IC₅₀ values are means ± standard deviations (of three replicate measurements).