Table of Contents
International Journal of Inorganic Chemistry
Volume 2012, Article ID 106187, 8 pages
http://dx.doi.org/10.1155/2012/106187
Research Article

Mixed-Ligand Nickel(II) Complexes Containing Sulfathiazole and Cephalosporin Antibiotics: Synthesis, Characterization, and Antibacterial Activity

Departamento de Química, Universidad de Oriente, Apartado Postal 208, Cumana, Venezuela

Received 30 November 2011; Revised 13 February 2012; Accepted 24 February 2012

Academic Editor: Peter Baran

Copyright © 2012 J. R. Anacona and Maried Lopez. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Nickel(II) reacts with cephalosporins plus sulfathiazole (Hstz) to form the following mixed-ligand complexes of general formulae [Ni(L)(stz) ( , ; , ; L = monoanion of cefazolin , cephalothin , cefotaxime , ceftriaxone ) and [Ni( )(stz)]Cl (cefepime ), which were characterized by physicochemical and spectroscopic methods. Their spectra indicated that cephalosporins are acting as multidentate chelating agents, via the lactam carbonyl and carboxylate and N-azomoieties. The complexes are insoluble in water and common organic solvents but soluble in DMSO, where the [Ni( )(stz)]Cl complex is 1 : 1 electrolyte. They probably have polymeric structures. They have been screened for antibacterial activity, and the results are compared with the activity of commercial cephalosporins.