Table of Contents
International Journal of Inorganic Chemistry
Volume 2012, Article ID 372141, 9 pages
Research Article

Synthesis, Characterization, and Antimicrobial and Antispermatogenic Activity of Bismuth(III) and Arsenic(III) Derivatives of Biologically Potent Nitrogen and Sulfur Donor Ligands

1Centre for Advanced Studies in Chemistry, University of Rajasthan, Jaipur 302004, India
2Department of Zoology, University of Rajasthan, Jaipur 302004, India

Received 7 November 2011; Revised 12 January 2012; Accepted 26 January 2012

Academic Editor: Hakan Arslan

Copyright © 2012 Latika Dawara et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


A series of Bi(III) and As(III) complexes with two NS donor ligands, 1-(4-chloro-2-oxo-2H-chromen-3-yl)-methylene)-thiosemicarbazide (L1H) and N-[1-(2-oxo-2H-chrome-3yl-ethylidene]-hydrazinecarbodithionic acid benzyl ester (L2H) have been synthesized by the reaction of BiCl3 and Ph3As with ligands in 1 : 1 and 1 : 2 molar ratios. All the synthesized compounds were characterized by elemental analyses, melting point determinations, and a combination of electronic, IR, 1H NMR, 13C NMR spectroscopic techniques, and X-ray diffraction for structure elucidation. In order to evaluate the effect of metal ions upon chelation, both the ligands and their complexes have been screened for their antimicrobial activity against the various pathogenic bacterial and fungal strains. The metal complexes have shown to be more antimicrobial against the microbial species as compared to free ligands. Both the ligands and their corresponding metal complexes have been tested for their antifertility activity in male albino rats. The marked reduction in sperm motility and density resulted in infertility. Significant alterations were found in biochemical parameters of reproductive organs in treated animals as compared to control group. It is concluded that all these effects may finally impair the fertility of male rats.