Research Article
Comparative Study on the MDR Reversal Effects of Selected Chalcones
Table 2
Reversal of MDR by chalcones 4–18 on mouse lymphoma cell line L 5178 T—dose-response experiments.
| Compound | Concentration [μg/mL] | Fluorescence activity (ratio) |
| Verapamil | 5.2 μM | 4.94 | 1 | 4 | 40.37a | 40 | 26.63a | 2 | 4 | 5.54a | 40 | 33.16a | 3 | 4 | 2.24a | 40 | 65.54a | 4 | 4 | 2.93 | 40 | 36.40 | 5 | 4 | 10.04 | 40 | 49.28 | 6 | 4 | 2.86 | 40 | 34.92 | 7 | 4 | 9.84 | 40 | 29.11 | 8 | 4 | 9.68 | 40 | 22.35 | 9 | 4 | 3.57 | 40 | 12.26 | 10 | 4 | 41.65 | 40 | 48.37 | 11 | 4 | 5.04 | 40 | 83.80 | 12 | 4 | 2.84 | 40 | 47.14 | 13 | 4 | 2.59 | 40 | 39.93 | 14 | 4 | 9.81 | 40 | 22.28 | 15 | 4 | 1.73 | 40 | 37.85 | 16 | 4 | 1.54 | 40 | 16.64 | 17 | 4 | 1.81 | 40 | 16.47 | 18 | 4 | 2.48 | 40 | 25.40 | DMSO control | 20 μL | 1.23 |
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aThe FAR values of chalcones 1, 2, and 3 were determined previously [8].
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