Comparative Study on the MDR Reversal Effects of Selected Chalcones

Table 4

Antiproliferative effects of chalcones 1–18 on L 5178 Y cells [μg/mL].

	Methoxylation pattern of ring A
𝑝-Substituent in ring B	3′,4′,5′-^a	2′,3′,4′-	2′,4′,6′-	2′,4′-	3′,4′-	2′,5′-
N(CH3)2	<0.19	0.42±0.14	≫50	43.18±1.48	>50	0.47±0.01
Cl	0.14	2.16±0.00	5.19±0.14	4.98±0.33	2.17±0.31	4.95±0.12
OCH3	<0.19	2.23±0.28	22.75±3.90	42.58±18.03	5.06±0.89	1.74±0.07

^aThe antiproliferative activity of chalcones having 3′,4′,5′-trimethoxylated pattern was determined previously [8].