International Journal of Medicinal Chemistry / 2011 / Article / Fig 1

Research Article

Synthesis, Molecular Modeling, and Biological Evaluation of Novel Tetrahydro-β-Carboline Hydantoin and Tetrahydro-β-Carboline Thiohydantoin Derivatives as Phosphodiesterase 5 Inhibitors

Figure 1

Conformational representation of the energy minimized form of compound VIII by MMF94 followed by conformational search, showing a semiperpendicular disposition of the pendant dimethoxyphenyl relative to the tetracyclic part. Torsional angle of 77.2°.

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