Synthesis, Molecular Modeling, and Biological Evaluation of Novel Tetrahydro-<i>β</i>-Carboline Hydantoin and Tetrahydro-<i>β</i>-Carboline Thiohydantoin Derivatives as Phosphodiesterase 5 Inhibitors

<table>Conformational representation of the energy minimized form of compound <b>VIII</b> by MMF94 followed by conformational search, showing a semiperpendicular disposition of the pendant dimethoxyphenyl relative to the tetracyclic part. Torsional angle of 77.2°.</table>

International Journal of Medicinal Chemistry

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Figure 1

Figure 1: Synthesis, Molecular Modeling, and Biological Evaluation of Novel Tetrahydro-<i>β</i>-Carboline Hydantoin and Tetrahydro-<i>β</i>-Carboline Thiohydantoin Derivatives as Phosphodiesterase 5 Inhibitors 

Figure 1 | Synthesis, Molecular Modeling, and Biological Evaluation of Novel Tetrahydro-β-Carboline Hydantoin and Tetrahydro-β-Carboline Thiohydantoin Derivatives as Phosphodiesterase 5 Inhibitors 