International Journal of Medicinal Chemistry / 2011 / Article / Fig 2

Research Article

Synthesis, Molecular Modeling, and Biological Evaluation of Novel Tetrahydro-β-Carboline Hydantoin and Tetrahydro-β-Carboline Thiohydantoin Derivatives as Phosphodiesterase 5 Inhibitors

Figure 2

detailed photo mode showing interaction of compound VIII with human PDE5 through H-bonding with Gln 817. The missing of π-π stacking with Phe820 may be the reason why this compound is less active than tadalafil.

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