Synthesis, Molecular Modeling, and Biological Evaluation of Novel Tetrahydro-<i>β</i>-Carboline Hydantoin and Tetrahydro-<i>β</i>-Carboline Thiohydantoin Derivatives as Phosphodiesterase 5 Inhibitors

<table>detailed photo mode showing interaction of compound VIII with human PDE5 through H-bonding with Gln 817. The missing of <i>π</i>-<i>π</i> stacking with Phe820 may be the reason why this compound is less active than tadalafil.</table>

International Journal of Medicinal Chemistry

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Figure 2

Figure 2: Synthesis, Molecular Modeling, and Biological Evaluation of Novel Tetrahydro-<i>β</i>-Carboline Hydantoin and Tetrahydro-<i>β</i>-Carboline Thiohydantoin Derivatives as Phosphodiesterase 5 Inhibitors 

Figure 2 | Synthesis, Molecular Modeling, and Biological Evaluation of Novel Tetrahydro-β-Carboline Hydantoin and Tetrahydro-β-Carboline Thiohydantoin Derivatives as Phosphodiesterase 5 Inhibitors 