Synthesis, Molecular Modeling, and Biological Evaluation of Novel Tetrahydro-β-Carboline Hydantoin and Tetrahydro-β-Carboline Thiohydantoin Derivatives as Phosphodiesterase 5 Inhibitors
detailed photo mode showing interaction of compound VIII with human PDE5 through H-bonding with Gln 817. The missing of π-π stacking with Phe820 may be the reason why this compound is less active than tadalafil.
Article of the Year Award: Outstanding research contributions of 2020, as selected by our Chief Editors. Read the winning articles.