Studies on 16α-Hydroxylation of Steroid Molecules and Regioselective Binding Mode in Homology-Modeled Cytochrome P450-2C11

Figure 2

The Homology-modeled structure of CYP2C11, in white solid ribon in sequence alignment with the solid ribon crystal structures of CYP2C9 (1og5) in cyan with its bound ligandSWF(s-warfarin), CYP2C9 (1og2) in violet, and CYP2C9 (1r9o) in yellow with its bound ligand, FLP (Flurbiprofen). Molecules of heme and Hec of the aligned proteins in red ball and stick are shown in exact superposition within the binding site.