International Journal of Medicinal Chemistry / 2012 / Article / Tab 3

Research Article

Syntheses and Biological Activity of Some Derivatives of C-9154 Antibiotic

Table 3

Minimum inhibitory concentration (above) and minimum bactericidal/fungicidal concentration (below) of the analogue and derivatives (μg/mL).

IA/01/1IA/24/1/BIA/21/1/BIA/22/1/BIA/23/1/BIA/19/1/BIA/20/1/BDMSOSparfloxacinFluconazole

MRSA2.50.6251.250.6250.6250.6250.625ND10ND
102.52.51.252.51.252.5

S. aureus2.50.6250.6250.6250.6250.6250.625ND10ND
52.52.52.52.52.52.5

S. pyogenes2.5ND0.6250.6250.625ND1.25ND10ND
10ND2.51.251.25ND2.5

B. subtilis1.251.250.6250.6250.6251.250.625ND5ND
551.252.52.52.51.25

C. ulceransND0.6251.251.250.625ND1.25NDNDND
ND2.52.52.52.5ND5

E. coli2.51.251.251.251.251.251.25ND10ND
52.52.5552.55

P. mirabilis2.51.251.251.251.250.6251.25ND10ND
1052.52.552.55

P. aeruginosaNDNDNDNDNDNDNDND10ND
NDNDNDNDNDNDND

S. typhii2.50.6251.251.250.6251.251.25ND10ND
52.552.52.52.55

S. dysenteriae2.51.251.250.6250.6250.6251.25ND5ND
102.52.51.252.52.55

K. pneumoniae2.51.251.250.6250.6251.251.25ND5ND
5552.52.52.52.5

C. albicans2.51.251.251.250.6251.251.25NDND25
10552.52.555

A. nigre2.5NDNDNDNDNDNDNDNDND
10NDNDNDNDNDND

T. rubrumNDNDNDNDNDNDNDNDND25
NDNDNDNDNDNDND

Upper values are MIC and lower values are MBC or MFC as the case may be. ND: not determined.

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