International Journal of Medicinal Chemistry / 2012 / Article / Tab 2

Research Article

Aurones: A Promising Heterocyclic Scaffold for the Development of Potent Antileishmanial Agents

Table 2

Antileishmanial activity and cytotoxicity of the synthesized aurones.

CompoundIC50 ( M)Selectivity index (SI)a
L. infantum intracellular amastigotesTHP1-differentiated macrophages

4andb nd
4bnd nd
4cnd nd
4dnd nd
4e 11.5
4fnd nd
4g 12.4
4hnd nd
4i 57.5
4j 43.4
4k >100>8.2
4l 26.9
Amphotericin B 20.6

aThe selectivity index represents the ratio of IC50 on THP1-differentiated macrophages to the IC50 on intracellular parasite.
bnd: not determined, for compounds with IC50 values below 20 μM on THP1-differentiated macrophages.

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