MDAN-21: A Bivalent Opioid Ligand Containing mu-Agonist and Delta-Antagonist Pharmacophores and Its Effects in Rhesus Monkeys

<table>Antinociceptive effects of methadone administered alone or after pretreatment with MDAN-21 in monkey M1472 (left panel) and M1475 (right panel). Abscissae: minutes after methadone administration. Ordinates: percent maximum possible effect. Each point shows the results from a single determination in each monkey.</table>

International Journal of Medicinal Chemistry

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Figure 4

Figure 4: MDAN-21: A Bivalent Opioid Ligand Containing mu-Agonist and Delta-Antagonist Pharmacophores and Its Effects in Rhesus Monkeys 