MDAN-21: A Bivalent Opioid Ligand Containing mu-Agonist and Delta-Antagonist Pharmacophores and Its Effects in Rhesus Monkeys

<table>Effects of MDAN-21 (left panel) and morphine (right panel) in an assay of capsaicin-induced thermal allodynia. Abscissae: minutes after removal of the capsaicin patch. Ordinates: percent maximum possible effect. Each point shows mean ± S.E.M. from three monkeys.</table>

International Journal of Medicinal Chemistry

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Figure 5

Figure 5: MDAN-21: A Bivalent Opioid Ligand Containing mu-Agonist and Delta-Antagonist Pharmacophores and Its Effects in Rhesus Monkeys 