Identification of a Novel Series of Potent TrkA Receptor Tyrosine Kinase Inhibitors

Table 3

Influence of the central phenyl ring substistution in the 6-acetamidopyridine series on the TrkA potency.

Cpd	𝐑^𝟏	𝐑^𝟐	TrkA^a; % inh. at 30 nM
5	H	H	96
10	Me	H	6
11	OMe	H	15
12	H	Cl	0

^apercentage of inhibition values are reported as the average of ≥3 experiments.