Table 5: Rat pharmacokinetic profile of compound 5.

PK propertiesaCpd 5

T1/2 (h), i.v.1.5
Cl (L/h/kg) i.v.3.3
Vss (L/kg) i.v.3.7
(h), p.o.4.0
N. [μM/(mg/kg)], p.o.0.08
N. AUC [μM.h/(mg/kg)], p.o.0.83
F (%)99

ai.v. dose: 2.58 mg/kg; p.o. dose: 5.25 mg/kg.