Identification of a Novel Series of Potent TrkA Receptor Tyrosine Kinase Inhibitors

Table 5

Rat pharmacokinetic profile of compound 5.

PK properties^a	Cpd 5
T1/2 (h), i.v.	1.5
Cl (L/h/kg) i.v.	3.3
Vss (L/kg) i.v.	3.7
𝑡max (h), p.o.	4.0
N. 𝐶max [μM/(mg/kg)], p.o.	0.08
N. AUC [μM.h/(mg/kg)], p.o.	0.83
F (%)	99

^ai.v. dose: 2.58 mg/kg; p.o. dose: 5.25 mg/kg.