A DFT and Semiempirical Model-Based Study of Opioid Receptor Affinity and Selectivity in a Group of Molecules with a Morphine Structural Core

Table 10

Beta coefficients and 𝑡-test for significance of coefficients in (20).

Variable	Beta coefficient	𝑡	𝑃
𝑆^𝑁7(LUMO+1)	0.45	3.96	<0.0027
𝑆^𝑁7	0.65	5.52	<0.0003
𝐹16(HOMO−1)	0.45	4.55	<0.0011
𝑆^𝑁11(LUMO+1)	0.29	3.01	<0.0130
𝑆^𝑁11(HOMO)	0.29	2.87	<0.0166