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International Journal of Medicinal Chemistry
Volume 2013, Article ID 201580, 10 pages
http://dx.doi.org/10.1155/2013/201580
Research Article

Synthesis of N-(6-(4-(Piperazin-1-yl)phenoxy)pyridin-3-yl)benzenesulfonamide Derivatives for the Treatment of Metabolic Syndrome

1Department of Medicinal Chemistry, Piramal Life Sciences Limited, 1 Nirlon Complex, Goregaon East, Mumbai 400 063, India
2Lupin Limited, Mumbai, India
3Department of Pharmacology, Piramal Life Sciences Limited, 1 Nirlon Complex, Goregaon East, Mumbai 400 063, India
4Department of DMPK, Piramal Life Sciences Limited, 1 Nirlon Complex, Goregaon East, Mumbai 400 063, India
5Department of Discovery Informatics, Piramal Life Sciences Limited, 1 Nirlon Complex, Goregaon East, Mumbai 400 063, India
6Institute of Biomedicine, Department of Physiology, Biocenter of Oulu, Faculty of Medicine, Oulu University, P.O. Box 5000, Aapistie 7, 90014 Oulu, Finland
7Department of Biochemistry, Haffkine Institute for Training, Research and Testing, Parel, Mumbai 400 012, India

Received 22 August 2013; Revised 16 October 2013; Accepted 24 October 2013

Academic Editor: Patrick Bednarski

Copyright © 2013 Nabajyoti Deka et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Metabolic syndrome is a widely prevalent multifactorial disorder associated with an increased risk of cardiovascular disease and type 2 diabetes mellitus. High plasma levels of insulin and glucose due to insulin resistance are a major component of the metabolic disorder. Thiazolidinediones (TZDs) are potent PPARγ ligand and used as insulin sensitizers in the treatment of type 2 diabetes mellitus. They are potent insulin-sensitizing agents but due to adverse effects like hepatotoxicity, a safer alternative of TZDs is highly demanded. Here we report synthesis of N-(6-(4-(piperazin-1-yl)phenoxy)pyridin-3-yl)benzenesulfonamide derivatives as an alternate remedy for insulin resistance.