Figure 6: Androstene hormones and dexamethasone activation of the human GR. Reporter cells were treated with dexamethasone alone or a combination of dexamethasone and androstene hormone, incubated for 24 hours, and then assayed for luciferase activity ( ). Androstene hormone activity was normalized to cellular uptake (Section 2.3.1). Error bars, ±1 SD. Statistical significance, is at least < 0.05 from other androstene hormone metabolites within the dexamethasone concentration treatment group (¤), is at least < 0.05 versus control ( ), is at least < 0.05 from 333 pM dexamethasone treatment group (●).