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International Journal of Medicinal Chemistry
Volume 2013, Article ID 256836, 7 pages
Research Article

Synthesis and Anticancer Properties of Silver(I) Complexes Containing 2,6-Bis(substituted)pyridine Derivatives

1Applied Organic Chemistry Department, National Research Centre, Dokki, Cairo 12622, Egypt
2Inorganic Chemistry Department, National Research Centre, Dokki, Cairo 12622, Egypt
3Department of Pharmacognosy, National Research Centre, Dokki, Cairo 12622, Egypt

Received 15 November 2012; Revised 6 February 2013; Accepted 7 February 2013

Academic Editor: Feng Liang

Copyright © 2013 Korany A. Ali et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Several new 2,6-bis(substituted)pyridine ligands and 2,6-bis(substituted)pyridine Ag(I) nitrate complexes were synthesized and characterized spectroscopically. The newly synthesized ligands include pyridine-2,6-bis(3-oxopropanenitrile) (1), pyridine-2,6-bis(2-cyano-N-phenyl-3-oxopropanethioamide) (2), and pyridine-2,6-bis((E)-2-(2-phenylhydrazono)-3-oxopropanenitrile) (3). The newly synthesized ligands and silver(I) complexes were evaluated for their in vitro anticancer activity against four human cancer cell lines including hepatocellular carcinoma (HePG2), lung adenocarcinoma (A549), colon carcinoma (HT29), and breast adenocarcinoma (MCF7). Most of the newly synthesized silver(I) complexes exhibited better activity than the ligands, and the results have been compared with doxorubicin as a reference drug.