International Journal of Medicinal Chemistry / 2013 / Article / Sch 2

Research Article

Synthesis Characterization and Antibacterial, Antifungal Activity of N-(Benzyl Carbamoyl or Carbamothioyl)-2-hydroxy Substituted Benzamide and 2-Benzyl Amino-Substituted Benzoxazines

Scheme 2

Synthesis of 7-N-substituted-1,3-oxazines 10-11 starting from 2-hydroxy-substituted benzoic acids 8 and 9. Reaction conditions: (i) compound a (Ac)2O, b PhCH=O, c 2-hydroxy-C6H4-CH=O, and d 3-ethoxy-2-hydroxy-C6H3-CH=O, (ii) Ph3P(SCN)2 in CH2Cl2, (iii) NaBH4, and (iv) Ph3P(SCN)2 in CH2Cl2.

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