The Development of Models Based on Linear and Nonlinear Multivariate Methods to Predict ADME/PK Properties Using Physicochemical Properties of Kinase, Protease Inhibitors, and GPCR Antagonists

Table 2

Correlation matrix for descriptors.

Variable	G. index	S. bonds	SAAA	YZ shadow	HASA-2	P. charge	O. atoms	R. O. atoms	N. atoms	R. N. atoms	A. bonds
G. index	1
S. bonds	0.26798	1
SAAA	0.41483	−0.0544	1
YZ shadow	0.50115	0.31235	0.21755	1
HASA-2	0.13998	−0.05302	−0.02074	0.18598	1
P. charge	−0.03232	−0.1199	0.03092	0.03528	0.30933	1
O. atoms	0.11838	0.09889	0.04789	−0.00181	0.12292	0.13269	1
R. O. atoms	−0.02622	−0.31383	0.05442	−0.14418	0.11698	0.16337	0.58024	1
N. atoms	0.21829	0.27275	0.02458	0.21158	0.50736	−0.10747	−0.11228	−0.29378	1
R. N. atoms	0.02254	−0.32032	0.05143	−0.01294	0.43585	−-0.10581	−0.24878	−0.1698	0.52116	1
A. bonds	0.2846	0.2069	0.00138	0.33825	0.14602	0.159	0.01585	−0.1204	−0.02972	−0.24046	1