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International Journal of Medicinal Chemistry
Volume 2013, Article ID 815453, 6 pages
http://dx.doi.org/10.1155/2013/815453
Research Article

Synthesis and Evaluation of Some Novel Chromone Based Dithiazoles as Antimicrobial Agents

1Bio-Organic and Photochemistry Laboratory, Department of Pharmaceutical Sciences, Guru Nanak Dev University, Amritsar, Punjab 143 005, India
2Department of Microbiology, Guru Nanak Dev University, Amritsar, Punjab 143 005, India

Received 10 August 2013; Revised 16 September 2013; Accepted 10 October 2013

Academic Editor: Qidong You

Copyright © 2013 Naureen Aggarwal et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Novel substituted 1,2,4-dithiazolylchromones 3a–j were synthesized by the reaction of 3-formylchromones (1a–j) with two equivalents of p-chlorothiobenzamide (2) in dry xylene and characterized spectroscopically (IR, 1H and 13C NMR, mass) and elemental analysis. All synthesized compounds were screened for in vitro antimicrobial activity against various pathogenic bacterial and fungal strains and were found to possess good to moderate inhibitory potential against all tested strains. Antimicrobial results reveal that compounds bearing lipophilic electron withdrawing groups such as chloro and bromo displayed significant inhibitory potential against both bacterial and fungal strains. Particularly, compound 3c displayed significant inhibitory against bacterial strains and compound 3h exhibits significant inhibitory potential in comparison to standard drug fluconazole against fungal strain S. cerevisiae.