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International Journal of Medicinal Chemistry
Volume 2013, Article ID 986536, 6 pages
Research Article

Novel Antimicrobial Agents: Fluorinated 2-(3-(Benzofuran-2-yl) pyrazol-1-yl)thiazoles

1Applied Organic Chemistry Department, National Research Centre, Dokki, Giza 12622, Egypt
2Department of Chemistry, Faculty of Science, Mansoura University, Mansoura 35516, Egypt
3Chemistry of Natural and Microbial Products, National Research Center, Dokki, Giza 12622, Egypt

Received 29 May 2013; Revised 10 August 2013; Accepted 11 August 2013

Academic Editor: Armando Rossello

Copyright © 2013 Hanan A. Mohamed et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


A new series of 2-pyrazolin-1-ylthiazoles 8a–d and 13–16 was synthesized by cyclization of N-thiocarboxamide-2-pyrazoline with different haloketones and 2,3-dichloroquinoxaline. The structures of the new compounds were confirmed by elemental analyses as well as NMR, IR, and mass spectral data. The newly synthesized compounds were evaluated for their antimicrobial activities, and also their minimum inhibitory concentration (MIC) against most of test organisms was performed. Amongst the tested ones, compound 8c displayed excellent antimicrobial activity.