Novel Antimicrobial Agents: Fluorinated 2-(3-(Benzofuran-2-yl) pyrazol-1-yl)thiazoles

Table 3

Minimum inhibitory concentration (μg/mL) against the pathological strains based on twofold serial dilution technique.

Chem. compds	Gram-positive bacteria				Gram-negative bacteria			Yeast
	Staphylococcus aureus ATCC29213	B. subtilis ATCC6633	B. megaterium ATCC9885	Sarcina lutea	Klebsiella pneumoniae ATCC13883	Pseudomonas aeruginosa ATCC27953	E. coli ATCC25922	Saccharomyces; cerevisiae	Candida albicans NRRL Y-477
5	200	—	200	100	100	100	100	100	200
8a	19	16	200	100	—	200	100	200	200
8b	100	200	—	50	200	200	100	200	—
8c	50	50	100	50	25	50	25	200	100
8d	50	—	—	100	—	200	100	200	200
13a	200	200	200	100	200	200	100	200	—
13b	100	200	50	100	100	200	100	200	—
14	200	200	200	100	100	100	50	100	200
15	200	—	200	10 0	100	200	50	200	200
16	200	—	20	100	100	200	50	200	—
Ciprofloxacin	25	25	25	25	25	25	25	N.A.	N.A.
Ketoconazole	N.A.	N.A.	N.A.	N.A.	N.A.	N.A.	N.A.	25	25