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International Journal of Medicinal Chemistry
Volume 2014, Article ID 202784, 31 pages
http://dx.doi.org/10.1155/2014/202784
Review Article

Significance and Biological Importance of Pyrimidine in the Microbial World

1School of Pharmacy, Lloyd Institute of Management & Technology, Plot. No. 11, Knowledge Park II, Greater Noida, Uttar Pradesh 201306, India
2Bioinformatics Centre, Biotech Park, Sector G, Jankipuram, Lucknow, Uttar Pradesh 226021, India
3Gautam Buddh Technical University, IET Campus, Sitapur Road, Lucknow, Uttar Pradesh 226021, India
4Department of Pharmaceutical Sciences, University Institute of Pharmaceutical Sciences, Kurukshetra University, Kurukshetra, Haryana 136119, India

Received 1 September 2013; Revised 13 January 2014; Accepted 14 January 2014; Published 23 March 2014

Academic Editor: Armando Rossello

Copyright © 2014 Vinita Sharma et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Microbes are unique creatures that adapt to varying lifestyles and environment resistance in extreme or adverse conditions. The genetic architecture of microbe may bear a significant signature not only in the sequences position, but also in the lifestyle to which it is adapted. It becomes a challenge for the society to find new chemical entities which can treat microbial infections. The present review aims to focus on account of important chemical moiety, that is, pyrimidine and its various derivatives as antimicrobial agents. In the current studies we represent more than 200 pyrimidines as antimicrobial agents with different mono-, di-, tri-, and tetrasubstituted classes along with in vitro antimicrobial activities of pyrimidines derivatives which can facilitate the development of more potent and effective antimicrobial agents.