Synthesis and Structural Activity Relationship Study of Antitubercular Carboxamides

Table 5

SAR and MIC of phenothiazine derived thiazolidinone carboxamides.

Compd. number	50 µg/L inhibition (%)	25 µg/L inhibition (%)	R = R^1
52	20	13
53	18	10
54a	22	18	C6H5
54b	32	25	4-ClC6H4
54c	34	27	3-ClC6H4
54d	35	30	2-ClC6H4
54e	40	28	4-BrC6H4
54f	50	27	3-BrC6H4
54g	52	25	2-BrC6H4
54h	65	32	4-NO2C6H4
54i	68	35	3-NO2C6H4
54j	66	38	2-NO2C6H4
54k	40	25	4-CH3OC6H4
54l	42	28	3-CH3OC6H4
54m	43	23	2-CH3OC6H4
54n	38	20	4-CH3C6H4
54o	35	24	3-CH3C6H4
54p	38	25	2-CH3C6H4
54q	50	28	4-HOCH3
54r	52	30	3-HOCH3
54s	55	32	2-HOCH3
55a	35	20	C6H5
55b	55	25	4-ClC6H4
55c	60	30	3-ClC6H4
55d	60	30	2-ClC6H4
55e	68	30	4-BrC6H4
55f	70	32	3-BrC6H4
55g	75	30	2-BrC6H4
55h	70	30	4-NO2C6H4
55i	68	35	3-NO2C6H4
55j	70	35	2-NO2C6H4
55k	50	30	4-CH3OC6H4
55l	53	32	3-CH3OC6H4
55m	50	30	2-CH3OC6H4
55n	41	29	4-CH3C6H4
55o	42	28	3-CH3C6H4
55p	45	30	2-CH3C6H4
55q	70	33	4-HOCH3
55r	70	34	3-HOCH3
55s	65	33	2-HOCH3
56a	45	22	C6H5
56b	74	32	4-ClC6H4
56c	80	36	3-ClC6H4
56d	80	32	2-ClC6H4
56e	78	30	4-BrC6H4
56f	79	30	3-BrC6H4
56g	76	29	2-BrC6H4
56h	82	32	4-NO2C6H4
56i	83	27	3-NO2C6H4
56j	81	28	2-NO2C6H4
56k	60	28	4-CH3OC6H4
56l	63	30	3-CH3OC6H4
56m	65	31	2-CH3OC6H4
56n	45	22	4-CH3C6H4
56o	49	18	3-CH3C6H4
56p	47	20	2-CH3C6H4
56q	76	24	4-HOCH3
56r	70	27	3-HOCH3
56s	65	25	2-HOCH3
Rifampicin		100
Isoniazid		100