Target Based Designing of Anthracenone Derivatives as Tubulin Polymerization Inhibiting Agents: 3D QSAR and Docking Approach

Table 2

3D QSAR model summary for statistically significant models.

Statistical parameter	Model A	Model B	Model C
Training set size	28	28	28
Test set size	8	8	8
𝑘-Nearest Neighbor	2	5	2
𝑛	28	28	28
Degree of freedom	24	23	23
𝑞^2	0.8330	0.8008	0.7722
𝑞^2_se	1.8935	2.0682	2.2119
Pred𝑟^2	0.7456	0.6923	0.8243
Pred_𝑟^2se	1.2660	1.3923	1.0521
Descriptor	S_692	E_448	S_1121
Range	−0.3789	−2.8750	−0.7512
	−0.3777	0.5249	−0.6729
	S_813	S_957	E_583
	−0.0707	−0.3844	10.0000
	−0.0675	−0.3073	10.0000
	S_714	E_1422	S_953
	30.0000	0.1359	2.3057
	30.0000	0.2768	15.4769
		E_213	E_1113
		0.0427	−3.7570
		0.7289	−3.6936