Research Article
Synthesis and Biological Evaluation of Aminonaphthols Incorporated Indole Derivatives
Table 1
Synthesis of
(disubstituted amino)(5-substituted 2-phenyl-1
H-indol-3-yl)methyl
naphthalene-ols (
4a–4r).
| Starting materials | Products (4a–4r) | Time (h) | Yield (%) isolated | Entry | Amines | R | Naphthol |
| 1 | Piperidine | H | 2-Naphthol | 4a | 3 | 82 | 2 | Piperidine | Cl | 2-Naphthol | 4b | 3 | 85 | 3 | Piperidine | CH3 | 2-Naphthol | 4c | 2 | 79 | 4 | Piperidine | H | 1-Naphthol | 4d | 2 | 89 | 5 | Piperidine | Cl | 1-Naphthol | 4e | 3 | 86 | 6 | Piperidine | CH3 | 1-Naphthol | 4f | 3 | 87 | 7 | Diethyl amine | H | 2-Naphthol | 4g | 3 | 90 | 8 | Diethyl amine | Cl | 2-Naphthol | 4h | 2 | 89 | 9 | Diethyl amine | CH3 | 2-Naphthol | 4i | 3 | 89 | 10 | Diethyl amine | H | 1-Naphthol | 4j | 3 | 78 | 11 | Diethyl amine | Cl | 1-Naphthol | 4k | 3 | 82 | 12 | Diethyl amine | CH3 | 1-Naphthol | 4l | 2 | 84 | 13 | Dimethyl amine | H | 2-Naphthol | 4m | 3 | 89 | 14 | Dimethyl amine | Cl | 2-Naphthol | 4n | 3 | 89 | 15 | Dimethyl amine | CH3 | 2-Naphthol | 4o | 3 | 85 | 16 | Dimethyl amine | H | 1-Naphthol | 4p | 3 | 88 | 17 | Dimethyl amine | Cl | 1-Naphthol | 4q | 3 | 84 | 18 | Dimethyl amine | CH3 | 1-Naphthol | 4r | 2 | 82 |
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