Research Article
Synthesis and Biological Evaluation of Aminonaphthols Incorporated Indole Derivatives
Table 5
Anticancer activity of compounds (4a–4r).
| | Compound | Concentration (g/mL) | OD at 492 nm | % of cell lysis |
IC50 (g/mL) |
| | 4b | 10 | 0.799 | 75% | 10 G | | 4b | 20 | 0.885 | 75% | | 4b | 30 | 1.559 | 100% | | 4e | 10 | 0.701 | 50% | 10 G | | 4e | 20 | 0.915 | 75% | | 4e | 30 | 1.010 | 75% | | 4h | 10 | 0.453 | 50% | 20 G | | 4h | 20 | 0.550 | 50% | | 4h | 30 | 0.799 | 75% | | 4k | 10 | 1.333 | 100% | Very 10 G | | 4k | 20 | 1.548 | 100% | | 4k | 30 | 1.873 | 100% | | 4n | 10 | 1.143 | 75% | 10 G | | 4n | 20 | 1.734 | 100% | | 4n | 30 | 1.822 | 100% | | 4q | 10 | 0.956 | 100% | Very 10 G | | 4q | 20 | 1.392 | 100% | | 4q | 30 | 1.752 | 100% | | 4r | 10 | 0.377 | No lysis | 20 G | | 4r | 20 | 0.606 | 50% | | 4r | 30 | 0.700 | 50% | | Control | — | 0.349 | No lysis | |
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Cell line-MDA-MB-human adenocarcinoma, mammary gland.
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