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International Journal of Medicinal Chemistry
Volume 2014, Article ID 721834, 5 pages
http://dx.doi.org/10.1155/2014/721834
Research Article

Docking Studies and Biological Activity of Fosinopril Analogs

1Department of Chemistry, Manipal College of Pharmaceutical Sciences, Manipal University, Manipal 576104, India
2Department of Pharmacology, Manipal College of Pharmaceutical Sciences, Manipal University, Manipal 576104, India

Received 30 September 2013; Revised 12 May 2014; Accepted 13 May 2014; Published 6 July 2014

Academic Editor: Maria Cristina Breschi

Copyright © 2014 Jayant Choudary et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

The purpose of the present study was to determine the angiotensin-I converting enzyme inhibitory activity of few novel Fosinopril derivatives which were predicted to possess better ACE inhibitory activity and lesser side effects than the existing drug molecule. In vitro study was carried out to determine ACE inhibitory activity of six different Fosinopril analogs by spectrophotometric assay procedure. Analog A2 showed the highest activity compared to other analogs and as well as Fosinopril itself. Docking studies of the compounds were done with the help of VLife MDS 3.0 software using GRIP batch docking method to find out which derivative had a better docking with ACE. The compounds which showed the highest negative score in docking have also exhibited good ACE inhibitory activity.