Synthetic Antimicrobial Peptides Exhibit Two Different Binding Mechanisms to the Lipopolysaccharides Isolated from Pseudomonas aeruginosa and Klebsiella pneumoniae

Table 1

Definition of the RESIDUES found in the Six Tic-Oic containing analogs.

AMP number	Residue A^1	Residue B^2	Residue C^3	Residue D^4	Residue E^5
22	None	None	None	None	Lys/Arg
70	None	None	None	None	Lys
71	None	None	None	None	Orn
72	None	None	None	None	Dpr
73	None	None	None	None	Dab
74	Gly	None	None	None	Lys
75	None	None	Gly	None	Lys
76	Gly	None	Gly	None	Lys
77	None	None	None	Gly	Lys
78	None	Gly	None	None	Lys
79	None	Gly	None	Gly	Lys
80	None	-Ala	None	Gly	Lys

(1) Residue A is the residue preceding each internal Lys residues (N-terminal side of the Lys).
(2) Residue B is the residue following each internal Lys residues (C-terminal side of the Lys).
(3) Residue C is the residue preceding each internal Phe residue (N-terminal side of the Phe).
(4) Residue D is the residue following each internal Phe residues (C-terminal side of the Phe).
(5) Residue E replaces the charged Lys residues with charged residues with progressively shorter side chains.