Synthetic Antimicrobial Peptides Exhibit Two Different Binding Mechanisms to the Lipopolysaccharides Isolated from Pseudomonas aeruginosa and Klebsiella pneumoniae
Table 3
In vitro minimum inhibitory concentration (MIC) and minimum bactericide concentration (MBC) activity against K. pneumonia and P. aeruginosa.
AMP
K. pneumoniae BAMC 07-18
P. aeruginosa PAO1
MIC (g/mL)/(M)
MBC (g/mL)/(M)
MIC (g/mL)/(M)
MBC (µg/mL)/(M)
22
>100
>100
>100
>100
70
>100
>100
>100
>100
71
100/31.2
>100
100/31.2
>100
72
100/33.6
100/33.6
50/16.8
100/33.6
73
50/16.2
100/32.4
50/16.2
100/32.4
74
>100
100/28.6
>100
>100
75
>100
100/29.2
50/14.6
50/14.6
76
50/13.9
50/13.9
50/13.9
50/13.9
77
50/14.6
100/29.2
50/14.6
50/14.6
78
50/14.3
100/28.6
50/14.3
50/14.3
79
50/13.9
50/13.9
50/13.9
50/13.9
80
50/13.8
50/13.8
25/6.9
50/13.8
Concentration values for MIC and MBC valves shown in light face are given in g/mL. Concentration values for MIC and MBC valves shown in italic font are given in M.
