Design and Synthesis of Novel Antileishmanial Compounds

Scheme 7

Synthesized analogs (31 to 35) of the assumed pharmacophore moiety. Reagents and conditions: (a) 3,3-dimethylbutanoylchloride, NEt₃, DCM (dry), 0–25^°C; (b) (rac)-1,4-dibromopentane, NaH, DMF (dry), 0–25^°C; (c) NaN₃, DMF (dry), 25^°C; (d) PPh₃, MeOH (dry), 25^°C.