Design and Synthesis of Novel Antileishmanial Compounds

Scheme 9

All active molecules of the study and reference drugs miltefosine (1) and pentamidine (2) in order from highest (11; 2.9 times more active than 1) to lowest (21; 2.8 times less active than 1) activity against promastigotes of L. major (against amastigotes of L. major: 12 < 11 < 8 < 5).