A Review of the Updated Pharmacophore for the Alpha 5 GABA(A) Benzodiazepine Receptor Model

<div>PWZ-029 docked with interactions. (1) HIS 105 <i>π</i>-stacking interaction with centroid of PWZ-029. (2) TYR 213 phenol OH hydrogen bonding to imidazole nitrogen lone pair. (3) THR 210 OH and lone pair on methoxy of PWZ029. (4) <i>α</i>5 ribbon being green. (5) <i>γ</i>2 ribbon being yellow. (6) Hydrogen bonding being aqua blue. (7) <i>π</i>-stacking being magenta.</div>

International Journal of Medicinal Chemistry

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Figure 16

Figure 16: A Review of the Updated Pharmacophore for the Alpha 5 GABA(A) Benzodiazepine Receptor Model 