A Review of the Updated Pharmacophore for the Alpha 5 GABA(A) Benzodiazepine Receptor Model

Figure 8

The effects of PWZ-029 (1) (2, 5 and 10 mg/kg) on (a) time exploring familiar and novel objects and (b) discrimination indices in the novel object recognition test using a 24 h delay (mean + SEM). Significant differences are indicated with asterisks (paired-samples -test, novel versus familiar, , , ). A significant difference from zero is indicated with hashes (one sample -test, ). The number of animals per each treatment group was 10. SOL = solvent [25].

(a)

(b)