A Review of the Updated Pharmacophore for the Alpha 5 GABA(A) Benzodiazepine Receptor Model

Figure 9

The effects of 0.3 mg/kg scopolamine (SCOP 0.3) and combination of 0.3 mg/kg scopolamine and PWZ-029 (1) (2, 5, and 10 mg/kg) on the rats’ performance in the object recognition task after a 1 h delay: (a) time exploring familiar and novel objects and (b) discrimination index. Data are represented as mean + SEM. Significant differences are indicated with asterisks (paired-samples -test, novel versus familiar, , ). A significant difference from zero is indicated with hashes (one sample -test, ). The number of animals per each treatment group was 12–15. SAL = saline, SOL = solvent [25].

(a)

(b)