A Review of the Updated Pharmacophore for the Alpha 5 GABA(A) Benzodiazepine Receptor Model

Scheme 4

Synthesis of bivalent analogues of DMH-D-053 (63). Reagents and Conditions. (a) 2 N NaOH, EtOH, and reflux; (b) 10% aq. HCl; (c) CDI, DMF; (d) diol, DBU; (e) trimethylsilylacetylene, Pd(OAc)₂(PPH₃)₂, Et₃N, CH₃CN, and reflux; (f) TBAF0.5H₂O, THF, −78°C.