Table 3: Binding affinity at αβ2γ2 receptor subtypes (values are reported in nM).

Compoundα1α2α3α4α5α6

SH-053-R-CH3, (15)202623771183>5000949.1>5000
SH-053-S-CH3, (16)166612631249>5000206.4>5000
SH-053-2′F-R-CH3, (2)759.1948.2768.8>500095.17>5000
SH-053-2′F-S-CH3, (17)3501411237>500019.2>5000

Data shown here are the means of two determinations which differed by less than 10%.