Research Article
Design and Synthesis of Novel Hybrid Molecules against Malaria
Scheme 2
Synthesis of the hybrid compounds 9 and 10. Reagents and conditions: (a) H2 (g), Pd/C, MeOH (dry), 25°C; (b) 4,7-dichloroquinoline (0.7 equivalents), neat, 120°C; (c) 4,7-dichloroquinoline (3 equivalents), neat, 120°C.