Research Article
Design and Synthesis of Novel Hybrid Molecules against Malaria
Scheme 4
Synthesis of the hybrid substance 14, starting with the reduction of the key intermediate 12 and followed by the linkage to the chloroquine motif. Reagents and conditions: (a) LiAlH4, THF (dry), 80°C; (b) 4,7-dichloroquinoline, neat, 120°C.